Substance sheet

Substance	Other names	Description	Use Case	Mechanism	Drug Interactions	LD50	Effective dosage daily	Effective dosage mg/kg	Supplier	Price	Price per dose	Food source	Sourcing	Resources
10-MeO-Harmalan	6-Methoxy-Harmalan
6-keto P4	6-oxo-progesterone; pregn-4-ene-3,6,20-trione
Activated Charcoal Powder
Adamantane	Diamondoid	Simplest known diamondoid; extremely lipophilic; core structure of antiviral/Parkinson drugs	Water-structuring, anti-excitotoxic, HDAC inhibitor, anti-cortisol, anti-serotonin, pro-dopamine, anti-viral, anti-diabetic	NMDA antagonist, σ1 receptor agonist, tyrosine hydroxylase stimulator	Enhances absorption of steroids/vitamins/drugs due to lipophilicity		33mg (20 drops of Diamant)		IdeaLabs (Diamant)
Allopregnanolone	ALLO, 5α-pregnan-3α-ol-20-one	Most potent endogenous GABA agonist; neurosteroid from progesterone	Anxiety, depression, Alzheimer's, epilepsy, PTSD, anti-endotoxin (TLR4 antagonist)	GABA-A receptor positive allosteric modulator		Safe to 10mg (men), 14mg (women) weekly IV	4mg weekly (Alzheimer's trial); 1mg/drop topical		IdeaLabs (AlloP)
Androsterone		Testoid; one of the two most active natural androgens alongside testosterone	Prostatic support, anesthesia tolerance	Unlike testosterone (more active on seminal vesicles), androsterone has a relatively greater pro-prostatic effect; thyroid (T3) increases conversion of other testoids into androsterone; in castrated rabbits, both estrone and androsterone increase tolerance to ether anesthesia
Apigenin		Flavone; aromatase inhibitor	Estrogen control, skin health, anti-cancer, anti-inflammatory	Aromatase inhibition, COX-2 inhibition, NO inhibition	Synergistic with naringenin and caffeine		2-3mg topical		IdeaLabs (MelaNon)				Guavas, celery, parsley, chamomile
Aspirin	Acetylsalicylic acid	NSAID; blocks prostaglandin synthesis	Anti-inflammatory, anti-cancer, anti-cortisol, anti-aromatase, protects against white matter hyperintensity and general brain aging	Inhibits prostaglandin synthesis, opposing PUFA-driven aromatase activation (raises testosterone under stress); increases carbon dioxide and oxidation of glucose to CO2, decreasing lactic acid formation; blocks prostaglandins that cause bone resorption; can substitute for calcium, thyroid, progesterone, and pregnenolone when those aren't available			500 mg daily (up to 1 g safe with a meal, dissolved); 5 g investigated for cancer						USP powder: Health Natura, AniPrin P (unflavored). Uncoated 325 mg tablets with corn starch filler: GeriCare, Pharbest, Health A2Z.
ATP	Adenosine triphosphate	Universal cellular energy carrier; central adsorbent in Ling's association-induction hypothesis of the cell	SIBO/gut motility, hair loss (topical), cancer cachexia, alcohol/liver protection	Directly inhibits intestinal bacterial overgrowth; reduces tumor reliance on glycolysis; orally absorbed and raises tissue ATP; topical succinic acid precursor raises follicle ATP and promotes hair regrowth			200mg (as IdeaLabs Cardenosine, 40 drops)		IdeaLabs (Cardenosine)					Fructose and thyroid (T3) both directly increase intestinal ATP synthesis
Baking Soda	Sodium bicarbonate, NaHCO₃						½ teaspoon dissolved in water or juice (not milk)
Beta-lapachone	Lapachone, β-Lapachone	Naphthoquinone from Pau D'Arco; relative of vitamin K	Cancer (pancreatic, melanoma, glioblastoma), NAD elevation, anti-viral, anti-bacterial, anti-fungal	Stimulates respiration, raises NAD levels					IdeaLabs (Lapodin)			Pau D'Arco/Tabebuia tree
BPC-157
bromocriptine	Ergot-derived dopamine agonist	Lowers prolactin, breast cancer, hair loss/graying, migraine	One minute of bromocriptine irreversibly inhibits prolactin release for hours; as a dopamine agonist and partial serotonin antagonist, achieved over 50% cure rates against native and transplanted breast tumors in animal studies, causing complete regression of primary tumors and metastases; used with vitamin B6, aspirin, and endotoxin/serotonin reduction for reversing hair loss and graying via prolactin suppression	Intravaginal administration avoids the gastrointestinal side effects of oral dosing in cases where oral bromocriptine isn't tolerated
Caffeine		Adenosine receptor antagonist; metabolic stimulant	Increase metabolism (similar to DNP), wakefulness, dopaminergic, liver function test	Adenosine antagonist; increases cAMP; inhibits serotonin synthesis via dopamine	Poor tolerance = poor liver function	Very high	100-400mg typical; metabolic: 1200-1400mg divided	~1.5-5 mg/kg	Bulk; coffee			Coffee, tea, chocolate		Half-life 3.5-5hr healthy; longer with poor liver
Calcium Carbonate		Alkaline calcium salt	Bone health, anti-PTH, anti-cortisol, counters estrogen-driven soft-tissue calcium deposition	Low dietary calcium triggers increased parathyroid hormone (PTH) production, which mobilizes calcium from the skeleton and makes bone more porous; estrogen decreases bone renewal and promotes calcium deposition in soft tissue instead, partly via stimulating prolactin, which breaks down bone to release calcium
Camphoric Acid, FG
Casein Protein	Main protein of milk	Anti-stress, sleep support	Anti-stress; direct anti-cortisol effect, distinct from milk's calcium content	Has direct anti-stress effects on its own, separate from the antistress amino acid balance of milk generally; part of a pre-sleep routine, paired with milk's calcium (pro-metabolic, lowers parathyroid hormone)									Milk
CBDA
Coca
Cocoa	Chocolate liquor/powder	Contains theobromine and caffeine	Magnesium source, mild stimulant	A very good source of magnesium, alongside coffee									Cacao beans
Cocoa Bean Extract		Concentrated cocoa extract	Magnesium source, mild stimulant	Same magnesium/theobromine/caffeine profile as whole cocoa, in concentrated form									Cacao beans
Coconut Water Powder
Creatine Monohydrate (Micronized)		Bioenergetic compound; FDA-approved ergogenic	Traumatic brain injury/nerve regeneration, ATP support	Crosses the blood-brain barrier and rapidly regenerates ATP from ADP independent of mitochondrial transport; in animal traumatic-nerve-injury models, creatine facilitated axonal regeneration and restored motor function by addressing the depleted energy reserves and mitochondrial dysfunction that otherwise cause "permanent" nerve damage			Animal studies used a human-equivalent dose of about 10–15 g daily for 8 weeks
Cyproheptadine (HCl)	Periactin	Anti-serotonin, anti-histamine (H1/H2), anti-cholinergic, calcium channel blocker	Serotonin syndrome (only drug to stop it), cancer support, autism, schizophrenia, depression, sleep, appetite	5-HT antagonist, H1 antagonist, muscarinic antagonist, Ca2+ channel blocker	Suppresses prolactin, GH, aldosterone, ACTH, TSH, cortisol; prostaglandin inhibitor		Start 0.5mg bedtime; therapeutic 2-4mg; max 4mg		Prescription (generic)					Effects can last days after single dose
Cyproheptadine (Hcl), USP							0.5–1 mg typical; 4 mg max, lower if serotonergic symptoms appear
DHEA	Dehydroepiandrosterone	"Youth-associated" protective steroid, alongside pregnenolone and progesterone; more easily absorbed topically than pregnenolone	Skin anti-aging (topical), anti-cortisol/anti-stress support, adaptogenic	Topical DHEA raises androgen receptor levels and procollagen in skin with only limited local conversion into other sex steroids, unlike high-dose oral DHEA which risks hyperestrogenicity; improves the efficiency of blood circulation, like progesterone			1–2 mg					IdeaLabs (CortiNon, progesterone:DHEA combination)
DHT	Dihydrotestosterone	Non-aromatizable androgen; can't convert to estrogen	Anti-estrogen buffer during metabolic stress, similar role to DHEA	Rises to buffer the effects of metabolic stress as an anti-estrogen, since unlike testosterone it can't be converted into estrogen; topical testosterone products show disproportionately high DHT because skin strongly expresses 5-alpha-reductase, which converts testosterone locally to DHT			1 mg
DMDA
DMSO	Dimethyl sulfoxide
DPPC	Dipalmitoylphosphatidylcholine
DSPC	Distearoylphosphatidylcholine
Emodin		Anthraquinone from rhubarb	Anti-inflammatory, anti-cancer, anti-viral, anti-angiogenic, increased ATP synthesis	Inhibits NO synthesis, fatty acid synthase, HER-2 neu; increases mitochondrial respiration					IdeaLabs (Lapodin)			Rhubarb, cascara
Ethanol
Ethyl Acetoacetate
Ethyl Pyruvate
Eugenol
Fenclonine
Flavanone
flower of sulfer
Frankincense
Fructose		Simple sugar; component of sucrose; supports oxidative metabolism more effectively than glucose alone	Liver glycogen loading, protection against stress hyperglycemia, protective against PUFA toxicity, intestinal ATP synthesis	Increases carbon dioxide production and oxygen consumption more than glucose does; raises blood temperature; unlike glucose, produces only a mild rise in blood sugar (bolus doses of 50-150g produce only 3-11 mg/dl plasma fructose, vs. glucose spikes over 150 mg/dl)									Table sugar/sucrose (half fructose), fruit, honey
GABA	Gamma-aminobutyric acid	Chief inhibitory neurotransmitter in the brain; also protects peripheral tissues	Protection against excitotoxicity from PUFA, glutamate, estrogen, and stress; anxiety, sleep	PUFA increase excitation and decrease the inhibitory action of the GABA system, interfering with mitochondrial energy production and driving glucose toward wasteful lactic acid conversion; GABAergic steroids act partly through mitochondrial "valium receptors"
Garlic	Allium sativum	Plant defensive-chemical toxin; popularly regarded as a health food, but not free of downsides	Antimicrobial (traditional use); documented mutagenicity/cytotoxicity in lab studies	Fresh garlic extract and diallyl trisulfide have shown cytotoxic and growth-inhibiting effects on cultured cells, and mutagenicity studies found garlic among the highest-activity substances tested, alongside black pepper
Garlic Extract		Concentrated garlic extract	Same profile as whole garlic, concentrated	Same mutagenicity/cytotoxicity caveats as fresh garlic apply to concentrated extracts
GHB
Ginger
ginseng
Glycine		Simplest amino acid; inhibitory neurotransmitter	Sleep (lowers core temp), blood sugar stabilization, collagen synthesis, schizophrenia, startle response	Inhibitory neurotransmitter (interchangeable with GABA in CNS); 5-AR upregulation		Toxic only at extreme doses (>200g estimated)	Sleep: 3g; per meal: 3-5g; collagen: 15g gelatin; schizophrenia: 60g	0.04-0.8 g/kg	Bulk supplements					Gelatin, collagen, bone broth (~3g/cup gelled broth)
Inosine
ivermectin
Ketamine
ketanserin
Ketotifen	Zaditen; nearly identical to cyproheptadine, milder on the liver/biliary tract	Antihistamine, mast cell stabilizer; histamine, leukotriene, and mild serotonin antagonist	Pancreas damage/digestion recovery, Hashimoto's and other autoimmune conditions	In a Russian study, restored pancreatic function and digestion impaired by anaphylactic shock (elevated histamine/adrenaline, which damage the pancreas); as a histamine/leukotriene antagonist that blocks estrogen's effects, may work for Hashimoto's and other "autoimmune" conditions driven by estrogen and histamine, similar to systemic sclerosis where it's shown effective			1-2mg daily (pancreas, human-equivalent dose from animal study); 2mg daily for 6 weeks (autoimmune, human trial); must be taken continuously or symptoms return
L-Deprenyl/Selegiline
L-Lysine
L-Pyroglutamic acid
l-theinine
L-Tyrosine
Lanosterol
Lidocaine
Lion's Mane Mushroom Extract
Lisuride (maleate)		Iso-ergoline; most potent dopamine agonist (D1-D5); serotonin antagonist	Lower prolactin, prevent migraines, anti-fibrotic (heart/liver/lung), Parkinson's, obesity reversal	D1-D5 agonist; 5-HT2B/6/7 antagonist ("inactivating" - persistent effect); H1/H2 antagonist	Effects persist after excretion; infrequent dosing effective		25-50mcg		IdeaLabs (Lisuride)					Store ≤20°C for 3+ month shelf life
LSD	Lysergic acid diethylamide; ergot/ergoline family, indole structure	Anti-serotonin, investigated for anxiety/depression and Alzheimer's	Ergot-family compounds including LSD block serotonin's constricting action on muscle tissues throughout the body	At doses similar to recreational use (~100mcg), a single dose has shown apparent anxiety/depression benefit in study settings, contrary to its reputation as purely damaging
Magnesium L-pidolate	Magnesium pidolate, oral form	Anti-stress mineral, needed alongside calcium, potassium, and zinc in the first stages of stress	Supports resistance to stress in its early stages; a high dietary magnesium-to-calcium ratio (as found in vegetables, bran, fruit) is desirable, alongside low phosphate intake									Vegetables, bran, fruit (for the magnesium/calcium ratio)
Magnesium sulfate	Epsom salt	Anti-stress mineral; can be given intravenously in emergencies	Same role as other magnesium forms in early-stage stress resistance
Metergoline		Serotonin antagonist	Serotonin syndrome (alternative to cyproheptadine), prolactin lowering	5-HT receptor antagonist			Rarer than cyproheptadine
Methyl myristate
Methyl oleate
Methyl palmitate
Methyl stearate
Methylene Blue	MB	First FDA drug (1890s); redox dye; can rewire mitochondrial respiratory chain	Depression, malaria, methemoglobinemia, shock resuscitation, bypass blocked respiratory chain	Electron carrier; MAO-A inhibitor; iNOS inhibitor; bypasses damaged mitochondrial enzymes	DO NOT combine with SSRIs (serotonin syndrome); high doses inhibit MAO-A	Very high (grams) in animals; no life shortening at ridiculous doses	Depression: 15mg; Product: 0.4mg/drop; Malaria (historic): 500mg/day		IdeaLabs (Oxidal)					Ray: "just take T3 instead"
Methylene Blue, USP							Microgram-range doses used
methysergide
myrrh
Naphthoquinones
Naringenin
Natural dessicated thyroid, USP
Niacinamide	Nicotinamide, Vitamin B3	NAD precursor; GABA agonist-like; SIRT1 inhibitor	Raise NAD, lower lactate, anti-cortisol, anti-anxiety, cancer metastasis prevention, diabetes, alcoholic liver disease	Raises NAD/NADH ratio; inhibits CD38/SIRT1; inhibits 11β-HSD1; enhances 11β-HSD2		Liver effects possible >3g/day	Maintenance: 100-200mg; Therapeutic: 500mg-1.5g; High trials: 3-4g	~15-40 mg/kg	Bulk supplements				Hoffer: 1,500mg daily optimal
Nicotine	Alkaloid, parasympathomimetic stimulant	Age-dependent: cautiously supportive in older age at low doses, anti-aromatase, anti-Parkinson's disease; main danger is the smoke, not the nicotine itself	Direct agonist of nicotinic acetylcholine receptors; at low doses (~1-2mg daily) inhibits aromatase and MAO-B, supporting dopamine tone; protects against excitotoxic calcium overload; typical replacement-product doses greatly exceed the protective range and shift it into a stress agent	Chronic overdosing raises free fatty acids and triggers adrenergic/cortisol stress responses	Mice (IP): ~10 mg/kg; Mice (oral): ~23-33 mg/kg	1-2 mg daily for cognitive/metabolic effects (non-smokers)						Tobacco leaf
ondansetron
Organic Matcha Powder
Oyster Extract		Concentrated shellfish extract	Copper deficiency correction	Oysters (or other shellfish) once or twice a week corrects a copper deficiency									Shellfish (oysters, shrimp)
pine pollen
Pregnenolone	P5	Mother hormone; precursor to all steroids; neurosteroid	Stress reduction (most potent CRH inhibitor), memory, anti-inflammatory, arthritis, anti-cancer	CRH inhibitor; TLR4 antagonist; converts to progesterone/DHEA	Brain levels 100x serum; intrinsic effects even when 5-AR blocked	No toxicity even at kg doses in animals	Maintenance: 30mg; Therapeutic: 100-150mg; 300mg lasts ~1 week	~1.5-2 mg/kg	Ray sourced from Syntex factory 1984-85				Few people <40s notice effects
Progesterone	P4	Not just pregnancy hormone; important for both sexes; aromatase inhibitor	PMS, menopause, anti-cancer, anti-estrogen, anti-cortisol, neuroprotection, fertility	Aromatase inhibitor; GABA agonist; estrogen receptor antagonist	High doses very sedating (anesthesia-like)	Extremely safe; no harmful side effects except cycle alteration	Women PMS: 10-12mg luteal; Men: 3-6mg; therapeutic: up to 100mg+	0.15-1.5 mg/kg	1940s - fertility/arthritis use	IdeaLabs (Progestene); various				Best dissolved in vitamin E; absorbed lymphatically
Quinine	As quinine hydrochloride, CAS 6119-47-7
Reishi Mushroom Extract
Retinyl acetate
Retinyl palmitate
Royal Jelly	Queen bee food	Richest known natural source of pantothenic acid; converts an ordinary bee larva into a fertile queen with a 6-8 year lifespan, versus a short-lived sterile worker on ordinary food	Rheumatoid arthritis (injected, with calcium pantothenate), fertility/longevity	18 vegetarian rheumatoid arthritics injected with royal jelly plus calcium pantothenate showed rapid symptom disappearance within 14 days, alongside a rise in blood pantothenic acid; devoid of significant vitamin E but a relatively rich source of most B vitamins
Royal Jelly Powder		Dried form of royal jelly	Same profile as fresh royal jelly, in powdered form
Salicylic acid, USP	2-Hydroxybenzoic acid
Salol, FG	Phenyl salicylate
Salt	Sodium chloride, NaCl						To taste
Stearic acid
Succinic acid
T3	Liothyronine sodium, USP
T4	Levothyroxine sodium, USP
Taurine		GABA analog; amino acid	Blood pressure, glycogen storage (doubles it), dopamine synthesis, insulin sensitivity, thyroid (reverses fluoride damage), T4→T3 conversion	Increases cAMP; increases dopamine synthesis; GABA agonism	Combines well with caffeine		BP: 1.6g; Insulin: 3-5g; GABA effect: 1g; Fluoride reversal: 15-30mg/kg	~20-70 mg/kg		Bulk supplements
Testosterone		Primary male androgen; precursor to both DHT (via 5α-reductase) and estrogen (via aromatase)	Low testosterone support, anti-cortisol, anti-estrogen (arthritis, autoimmune conditions)	Some fraction aromatizes to estrogen unless shielded by adequate thyroid/anti-stress status, so raising testosterone without addressing estrogen clearance can backfire; androgens including testosterone and DHT show anti-inflammatory, anti-estrogenic effects comparable to steroidal aromatase inhibitors in arthritis/autoimmune contexts									Oil or cream preferred over injectable esters (usually dissolved in a toxic solvent)
theobromine
thiamine	Vitamin B1	Water-soluble B vitamin; OTC carbonic anhydrase inhibitor	Alcohol intoxication/cravings, lowers lactate, raises CO2	Effective carbonic anhydrase inhibitor, which likely explains its common use for acute alcohol intoxication and alcohol cravings; increases CO2 and reduces lactate, part of the same protocol as niacinamide (lowers free fatty acids), sugar (lowers cortisol/adrenaline/free fatty acids), salt (lowers adrenaline), and thyroid hormone (raises CO2)
Tobacco	Contains nicotine	Laxative, anti-inflammatory (non-smoked forms)	Carbon monoxide isn't likely to be absorbed in dangerous amounts if the smoke isn't inhaled	Safest forms are transdermal or oral rather than smoked/inhaled; has a laxative and anti-inflammatory effect via those routes									Tobacco leaf
Trehalose
Triquinoyl hydrate
TUDCA
Vanilla
Vitamin A					Transported on the same protein as T3/thyroid hormone; absorption depends on adequate liver PUFA status being low
Vitamin B1 (Allithiamine)	TTFD, thiamine tetrahydrofurfuryl disulfide	Naturally-occurring lipophilic thiamine analog, found in garlic-family plant bulbs (source of their characteristic odor)	Physical activity, wakefulness, dopamine support	Lipophilic B1 forms, more than water-soluble thiamine itself, enhance physical activity and wakefulness by raising dopamine									Garlic-family plant bulbs
Vitamin B1 (Benfotiamine)	Synthetic lipophilic thiamine analog	Physical activity, wakefulness, dopamine support	Synthetic lipophilic B1 analog, along with allithiamine, sulbutiamine, and fursultiamine, studied since the mid-20th century in Japan for enhancing physical activity and wakefulness via dopamine
Vitamin B1 (Prosultiamine)	Prosultiamine						10 mg typical; up to 100 mg for marked deficiency
Vitamin B12	Cobalamin	Cobalt-containing B vitamin; needed for hemoglobin production and nerve function	Anemia prevention, nerve health	Adequate protein intake prevents B12 from being lost in the urine, while low-protein diets accelerate its loss; vitamins B6 and C increase B12 absorption									Liver, meat, other animal foods
Vitamin B2 (Riboflavin-5-Phosphate)	Riboflavin-5-phosphate
Vitamin B3 (Niacinamide)	Niacinamide, nicotinamide						1–200 mg
Vitamin B5 (D-Panthenol)	D-Panthenol
Vitamin B6 (Pyridoxal-5-Phosphate)	Pyridoxal-5-phosphate
Vitamin B7 (Biotin)	Biotin
Vitamin B8 (Inositol)
Vitamin D3	Cholecalciferol	Steroid-like fat-soluble vitamin/hormone, made when sunlight hits cholesterol in the skin	Calcium/phosphate regulation, immune support, skin cancer prevention	Old people need more vitamin D because aging skin has roughly half the cholesterol of young skin, so it makes only about half as much vitamin D from the same sun exposure; deficiency in aging skin's local immune system contributes to skin cancer formation			4,000–6,000 IU					Made endogenously from cholesterol in skin via sunlight; also from animal foods
Vitamin E	Alpha-tocopherol	Fat-soluble antioxidant vitamin; protects membranes from PUFA peroxidation	Pneumonia/immune protection, PUFA protection, cancer/lifespan extension	Neutralizes PUFA peroxidation (~2mg vitamin E needed per gram dietary PUFA, more for more unsaturated fats); inhibits neutrophil-mediated lung inflammation; long-term intake linked to a P21-pathway anti-cancer effect extending lifespan	High doses (long-term) can deplete vitamin K, interfering with clotting		600–800 IU short-term for infection protection; ~2mg per gram dietary PUFA for general protection; up to 3,200 IU tolerated in trials without harm	6.5 mg/kg (human equivalent, lifespan study)
Vitamin K2	Menaquinone (MK-4 is the most potent extrahepatic tissue form)	Fat-soluble vitamin; some synthesized by intestinal bacteria	Raising serum androgens (with DHEA/pregnenolone), bone health	Phylloquinone (K1) must be converted to menaquinone (MK-4) by side-chain truncation and replacement with a geranylgeranyl group to become the most potent extrahepatic tissue form; combined with pregnenolone and DHEA (dissolved in DMSO, applied to the scrotum) it raises serum androgens (testosterone, DHT, androstenedione) significantly faster than oral or non-scrotal topical routes; high-dose vitamin E can deplete vitamin K
Willow bark extract
α-Naphthoflavone